Anoint with Affliction

In Commander, Anoint with Affliction is a narrow but efficient answer to the low-MV permanents that define early boards — mana dorks, Solemn Simulacrum, hatebears, and commanders that sit at 2–3 mana. Exile over destruction matters in a format loaded with recursion and indestructible text. Outside of Phyrexian-tribal shells, though, the conditional clause bites: you can't cast it reliably in a deck that doesn't consistently have a Phyrexian in play. In Pauper and Pioneer it's fringe consideration at best, where the format's faster threats don't always fall in the right MV window and competing removal options are stronger. Legacy and Vintage have better two-mana interaction at every angle.