Lost in Space

In Commander, Lost in Space punches above its weight: three mana to strand a problematic permanent is clean, and enchantment removal is less universal than artifact removal in most metas, so it sticks more often than you'd expect. The comes-into-play trigger means blink and flicker commanders get repeated exile effects, and sacrifice-to-destroy effects don't break the lock unless they target enchantments specifically. In competitive one-on-one formats like Legacy or Modern, the conditional nature of the lock — answer the enchantment, get your permanent back — makes it too fragile for serious play. Pauper and Pioneer players have cleaner options at the same slot, so Lost in Space is essentially a Commander card wearing a universal legality badge.