Distemper of the Blood
Sorcery
Target creature gets +2/+2 and gains trample until end of turn.
Madness 
(If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)
- CMC
- 2
- Mana cost
- Color identity
- R
- Rarity
- common
- Set
- Eldritch Moon
- Price
- $0.06
- EDHREC rank
- #15275
Distemper of the Blood cycles for one mana while slapping +2/+2 and haste onto a creature — you get a meaningful board effect and replace itself in the same motion. In Anje Falkenrath builds it's not a question of whether to include it; it's a free roll that fuels the madness engine at essentially zero cost.
Best Commanders
Commanders with the highest synergy
Anje Falkenrath
Anje Falkenrath's ability triggers on any madness card you discard, so Distemper of the Blood does double duty: it satisfies the discard outlet, untaps Anje, and lands a buff on whatever creature you need to push through damage that turn.
Format Analysis
Where it lives, where it can’t
| Format | Verdict |
|---|---|
| commander | legal |
| legacy | legal |
| modern | legal |
| pioneer | legal |
| standard | not legal |
| vintage | legal |
| pauper | legal |
| oathbreaker | legal |
Distemper of the Blood is legal everywhere from Pauper up, but the formats where it earns a slot are narrow. In Commander, Anje Falkenrath is essentially the entire reason to sleeve it — outside of madness-matters builds, a one-mana Aura that cycles is fine but competes with better cantrips. In Pauper it occupies a niche in aggressive madness shells where cycling redundancy and cheap haste matter, though it's not a format staple. Legacy, Modern, and Pioneer have faster, more impactful one-drops that crowd it out of serious consideration.
Key Combos
Combo lines featuring this card
Price Context
Current price
$0.06 bulk tier
At $0.06, Distemper of the Blood is deep bulk — buy a dozen and never think about it again. Bulk commons don't appreciate, but this one doesn't need to: the copies cost less than shipping, so there's no reason not to have them on hand for any madness build you assemble.
Explore
Sources
Mentioned
Updated . Data from Scryfall, EDHREC, and Commander Spellbook.